Ferry JJ, Herman BD, Carel BJ et al. Pharmacokinetic drug-drug interaction study of delavirdine and indinavir in healthy volunteers. J Acquir Immune Defic Syndr Hum Retrovirol. Elevated indirect bilirubin, infrequently associated with increased serum AST SGOT or ALT SGPT concentrations, reported. Autoimmune disorders such as Graves' disease, polymyositis, and Guillain-Barré syndrome have also been reported to occur in the setting of immune reconstitution; however, the time to onset is more variable, and can occur many months after initiation of treatment. Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with Crixivan.
ZERIT will harm your unborn baby. Maier H, Zangerle R "Pyuria in patients treated with indinavir is associated with renal dysfunction. Combination antiretroviral therapy cART therapy is recommended for all HIV-infected pregnant women to keep the viral load below the limit of detection and reduce the risk of perinatal transmission. When HIV is diagnosed during pregnancy in a woman who has never received antiretroviral therapy, cART should begin as soon as possible after diagnosis. The Health and Humans Services HHS Perinatal HIV Guidelines do not recommend indinavir for initial therapy in antiretroviral-naive pregnant women due to concerns regarding maternal kidney stones or maternal hyperbilirubinemia; if used, must be given in combination with low-dose ritonavir boosting during pregnancy although the optimal dose has not yet been established. Plasma concentrations of unboosted indinavir are decreased during pregnancy. In general, women who become pregnant on a stable cART regimen may continue that regimen if viral suppression is effective, appropriate drug exposure can be achieved, contraindications for use in pregnancy are not present, and the regimen is well tolerated. Monitoring during pregnancy is more frequent than in non-pregnant adults; cART should be continued postpartum.
All interaction studies conducted in healthy, HIV-negative adult subjects, unless otherwise indicated. Gerberding JL. Management of occupational exposures to blood-borne viruses. N Engl J Med. VIDEX EC or VIDEX didanosine may increase your risk for liver damage.
Paricalcitol: CYP3A4 Inhibitors Strong may increase the serum concentration of Paricalcitol. This information is not specific medical advice and does not replace information you receive from your health care provider. Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering itraconazole concurrently. Possibility of HIV resistance to indinavir and possible cross-resistance to other PIs. 1 Effect of indinavir therapy on subsequent therapy with other PIs under investigation.
This medication was prescribed for your particular condition. Do not use it for any other condition or give it to anybody else. Keep Crixivan and all medicines out of the reach of children. If you suspect that more than the prescribed dose of this medicine has been taken, contact your local poison control center or emergency room immediately. Area under the curve over 24 hours. The 10 mg dosage is not an approved dosage. Patients experienced relief of symptoms upon discontinuation of the medication. Use indinavir as directed by your doctor. Check the label on the medicine for exact dosing instructions. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Lapatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Lapatinib. Check with your pharmacist about how to dispose of unused medicine. Digestive System: liver function abnormalities; hepatitis including reports of hepatic failure see ; pancreatitis; jaundice; abdominal distention; dyspepsia. Pharmacokinetics not studied in patients with severe hepatic impairment. It is very important that your doctor check your progress at regular visits to make sure that indinavir is working properly. Blood and urine tests may be needed to check for unwanted effects. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Abacavir: Protease Inhibitors may decrease the serum concentration of Abacavir. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Indinavir can slow down the removal of other medications from your body, which may affect how they work. The optimal dosing regimen for use of indinavir in pediatric patients has not been established.
Dose reduction of rifabutin to half the standard dose consult the manufacturer's product circular for rifabutin and a dose increase of Crixivan to 1000 mg every 8 hours are recommended when rifabutin and Crixivan are coadministered. Lab tests, including liver function, cholesterol, complete blood cell counts, and CD4 counts, may be performed while you use indinavir. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 CYP3A4 is the major enzyme responsible for formation of the oxidative metabolites. AIDS and histologically confirmed PCP. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. gynera
Your name may need to be listed on an antiviral pregnancy registry when you start using this medication. Deyton L. Importance of surrogate markers in evaluation of antiviral therapy for HIV infection. JAMA. Zidovudine: Protease Inhibitors may decrease the serum concentration of Zidovudine. Condra JH, Schleif WA, Blahy OM et al. Dynamics of acquired HIV-1 clinical resistance to the protease inhibitor MK-639. J Acquir Immune Defic Syndr Hum Retrovirol. NiMODipine: CYP3A4 Inhibitors Strong may increase the serum concentration of NiMODipine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Toremifene. CYP3A4 Inhibitors Strong may increase the serum concentration of Toremifene. Cotton D, moderator. The use of protease inhibitors. AIDS Clin Care. Struvite stones can be serious, because they are often large stones and may occur with an infection. Medical treatment, including and removal of the stone, is usually needed for struvite stones. Pimavanserin: CYP3A4 Inhibitors Strong may increase the serum concentration of Pimavanserin. Indinavir: Atovaquone may decrease the serum concentration of Indinavir. vdom.info travatan
If you also take didanosine, take it 1 hour before or after you take indinavir, on an empty stomach. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Csajka C, Marzolini C, Fattinger K, et al. "Population pharmacokinetics of indinavir in patients infected with human immunodeficiency virus. Study conducted in subjects on maintenance. Luvox to treat obsessive-compulsive disorder.
Note: Relapsing infection may require at least 6 weeks of therapy Vannier 2012. How should I take alosetron Lotronex? Less than 1% of these patients had concomitant elevations in ALT or AST. Condra JH, Holder DJ, Schleif WA et al. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. Where can I get more information? Dose to be repeated no earlier than 3 days. CI: 50%, 86% lower than that observed 6 weeks postpartum. Six of these 11 55% patients had mean indinavir plasma concentrations 8 hours post-dose C min below assay threshold of reliable quantification. It may harm them. Dosage adjustment not necessary. Calcifediol: CYP3A4 Inhibitors Strong may increase the serum concentration of Calcifediol. Patients should be advised to remain under the care of a physician when using Crixivan and should not modify or discontinue treatment without first consulting the physician. Therefore, if a dose is missed, patients should take the next dose at the regularly scheduled time and should not double this dose. Therapy with Crixivan should be initiated and maintained at the recommended dosage. Medication Guide for a complete list of ingredients in ONGLYZA. Indinavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control eg, condoms if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Crixivan is an oral capsule used for the treatment of HIV Human Immunodeficiency Virus. HIV is the virus that causes AIDS acquired immune deficiency syndrome. Crixivan is a type of HIV drug called a protease PRO-tee-ase inhibitor. How does Crixivan work? Binds to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV. This results in the formation of immature, noninfectious viral particles. glucotrol purchase canada
ONGLYZA-treated patient who developed suspected foodborne fatal salmonella sepsis after approximately 600 days of ONGLYZA therapy. Rosenberg E, Cotton D. Primary HIV infection and the acute retroviral syndrome: the urgent need for recognition. AIDS Clin Care. Many drugs can interact with indinavir. Not all possible interactions are listed here. Have your and checked regularly while taking this medication. Discuss with your doctor how to monitor your own pressure and pulse. Patients with renal insufficiency: Patients with renal insufficiency have not been studied. Closely monitor patients with asymptomatic severe leukocyturia and perform frequent urinalysis; further diagnostic evaluation may be warranted. Discontinuation should be considered in all patients with severe leukocyturia. De Wit S, Debier M, De Smet M et al. Effect of fluconazole on indinavir pharmacokinetics in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. Salahuddin S, Hsu YS, Buchholz NP, Dieleman JP, Gyssens IC, Kok DJ "Is indinavir crystalluria an indicator for indinavir stone formation? Reyataz atazanavir sulfate US prescribing information. Bristol-Myers Squibb Company March, 2015. Indinavir interacts with many drugs. Gentle DL, Stoller ML, Jarrett TW, Ward JF, Geib KS, Wood AF "Protease inhibitor-induced urolithiasis. Fluticasone Nasal: CYP3A4 Inhibitors Strong may increase the serum concentration of Fluticasone Nasal. nifedipine buy canada
Fluticasone Oral Inhalation: CYP3A4 Inhibitors Strong may increase the serum concentration of Fluticasone Oral Inhalation. Management: Use of orally inhaled fluticasone propionate with strong CYP3A4 inhibitors is not recommended. Use of orally inhaled fluticasone furoate with strong CYP3A4 inhibitors should be done with caution. Monitor patients using such a combination more closely. Proc Natl Acad Sci USA. When there is no egg to be fertilized, pregnancy cannot occur. It also thickens the cervical mucus, making it difficult for sperm to enter the uterus. Your doctor may want to run some blood test on you. Let your doctor know if you have any yellowing of the eyes or skin or any abdominal pain. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of indinavir in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving indinavir. Theophylline Derivatives: Protease Inhibitors may decrease the serum concentration of Theophylline Derivatives. Exceptions: Dyphylline. Tetracycline: May decrease the serum concentration of Atovaquone. Ticagrelor: CYP3A4 Inhibitors Strong may decrease serum concentrations of the active metabolites of Ticagrelor. CYP3A4 Inhibitors Strong may increase the serum concentration of Ticagrelor. Hutchinson A, Murphy M, Harries R, Skinner CJ "Galactorrhoea and hyperprolactinaemia associated with protease-inhibitors. Levitra, Staxyn or by international labeling. See full drug interaction monograph for details. If you miss a dose, take it as soon as you remember unless it is more than 6 hours after the time you usually take the dose. In that case, skip the missed dose and resume your usual dosing schedule. Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children, US Department of Health and Human Services HHS. Guidelines for the use of antiretroviral agents in pediatric HIV infection February 12, 2014. Updates may be available at HHS AIDS Information AIDSinfo website. Terfenadine: CYP3A4 Inhibitors Strong may increase the serum concentration of Terfenadine.
Indinavir is an inhibitor of the cytochrome P450 isoform CYP3A4. Coadministration of Crixivan and drugs primarily metabolized by CYP3A4 may result in increased plasma concentrations of the other drug, which could increase or prolong its therapeutic and adverse effects see and . Based on in vitro data in human liver microsomes, indinavir does not inhibit CYP1A2, CYP2C9, CYP2E1 and CYP2B6. However, indinavir may be a weak inhibitor of CYP2D6. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Cyclophosphamide. Specifically, the incidences of neutropenia, infection, and mucositis may be increased. Canadian labeling: Additional contraindications not in US labeling: Coadministration with atazanavir, rifampin, and St. John wort. This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor. The study enrolled 1156 HIV-infected patients 17% female, 28% Black, 18% Hispanic, mean age 39 years. New onset or exacerbation of preexisting diabetes mellitus, glucose intolerance, and hyperglycemia have been reported during postmarketing surveillance in HIV patients treated with protease inhibitors PIs. Frequently, insulin resistance may accompany fat redistribution and serum lipid elevations in what is collectively termed the HIV-associated lipodystrophy syndrome. Although a causal relationship has not been established, these metabolic disturbances have most often occurred in HIV patients during treatment with potent antiretroviral regimens containing PIs. Patients with or predisposed to glucose disorders should be monitored during PI therapy. Dosage adjustments in insulin or oral hypoglycemic medications may be necessary in patients with diabetes. In some cases, glucose abnormalities persisted despite discontinuation of PI therapy. If you take didanosine, ask your doctor or pharmacist how to take it with indinavir. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Lercanidipine: CYP3A4 Inhibitors Strong may increase the serum concentration of Lercanidipine. Ruxolitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ruxolitinib. Management: This combination should be avoided under some circumstances. See monograph for details. Collin F, Chene G, Retout S, et al. "Indinavir Trough Concentration as a Determinant of Early Nephrolithiasis in HIV-1-Infected Adults. mirtazapine pills online purchase
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Talk to your pharmacist if you have questions about this information. Pimozide: CYP3A4 Inhibitors Strong may increase the serum concentration of Pimozide. Instruct HIV-infected women not to breast-feed because of risk of HIV transmission and risk of adverse effects in the infant. Not known whether distributed into human milk; 1 202 distributed into milk in rats. buy micronase boots chemist
Therefore, -feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication. Rilpivirine: CYP3A4 Inhibitors Strong may increase the serum concentration of Rilpivirine. Indinavir should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. Szczech LA "Hypertension and medication-related renal dysfunction in the HIV-infected patient.
Hengel RL, Watts NB, Lennox JL. Benign symmetric lipomatosis associated with protease inhibitors. Lancet. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. FDA pregnancy category B. Alosetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Gefitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Gefitinib. pyridium
Dabrafenib: CYP3A4 Inhibitors Strong may increase the serum concentration of Dabrafenib. Prasugrel: CYP3A4 Inhibitors Strong may decrease serum concentrations of the active metabolites of Prasugrel. Ocular side effects have included blurred vision, eye pain, eye swelling, and orbital edema. Viracept nelfinavir mesylate US prescribing information.